Implicit memory and cognitive aging

It is well documented that explicit (declarative, conscious) memory declines in normal aging. Studies have shown a progressive reduction in this form of memory with age, and healthy older adults (typically aged 65+ years) usually perform worse than younger adults (typically aged 18-30 years) on laboratory tests of explicit memory such as recall and recognition. In contrast, it is less clear whether implicit (procedural, unconscious) memory declines or remains stable in normal aging. Implicit memory is evident when previous experiences affect (e.g., facilitate) performance on tasks that do not require conscious recollection of those experiences. This can manifest in rehearsed motor skills, such as playing a musical instrument, but is typically indexed in the laboratory by the greater ease with which previously studied information is processed relative to non-studied information (e.g., repetition priming). While a vast amount of research has accumulated to suggest that implicit memory remains relatively stable over the adult lifespan, and is similar in samples of young and older adults, other studies have in contrast revealed that implicit memory is subject to age-related decline. Improving methods for determining whether implicit memory declines or remains stable with age is an important goal for future research, as the issue not only has significant implications for an aging society regarding interventions likely to ameliorate the effects of age-related explicit memory decline, but can also inform our theoretical understanding of human memory systems

Sum of Two Squares - Pair Correlation and Distribution in Short Intervals

In this work we show that based on a conjecture for the pair correlation of integers representable as sums of two squares, which was first suggested by Connors and Keating and reformulated here, the second moment of the distribution of the number of representable integers in short intervals is consistent with a Poissonian distribution, where "short" means of length comparable to the mean spacing between sums of two squares. In addition we present a method for producing such conjectures through calculations in prime power residue rings and describe how these conjectures, as well as the above stated result, may by generalized to other binary quadratic forms. While producing these pair correlation conjectures we arrive at a surprising result regarding Mertens' formula for primes in arithmetic progressions, and in order to test the validity of the conjectures, we present numericalz computations which support our approach.Comment: 3 figure

Treatment of falciparum malaria in the age of drug-resistance

The growing problem of drug resistance has greatly complicated the treatment for falciparum malaria. Whereaschloroquine and sulfadoxine/ pyrimethamine could once cure most infections, this is no longer true and requiresexamination of alternative regimens. Not all treatment failures are drug resistant and other issues such asexpired antimalarials and patient compliance need to be considered. Continuation of a failing treatment policyafter drug resistance is established suppresses infections rather than curing them, leading to increasedtransmission of malaria, promotion of epidemics and loss of public confidence in malaria control programs.Antifolate drug resistance (i.e. pyrimethamine) means that new combinations are urgently needed particularlybecause addition of a single drug to an already failing regimen is rarely effective for very long. Atovaquone/proguanil and mefloquine have been used against multiple drug resistant falciparum malaria with resistance toeach having been documented soon after drug introduction. Drug combinations delay further transmission ofresistant parasites by increasing cure rates and inhibiting formation of gametocytes. Most currentlyrecommended drug combinations for falciparum malaria are variants of artemisinin combination therapy wherea rapidly acting artemisinin compound is combined with a longer half-life drug of a different class. Artemisininsused include dihydroartemisinin, artesunate, artemether and companion drugs include mefloquine, amodiaquine,sulfadoxine/ pyrimethamine, lumefantrine, piperaquine, pyronaridine, chlorproguanil/dapsone. The standard ofcare must be to cure malaria by killing the last parasite. Combination antimalarial treatment is vital not only tothe successful treatment of individual patients but also for public health control of malaria

Evaluation of Constructed Depression Storage on Reduction of Storm Runoff Flows in an Urban Area

The objective of this study was to determine the degree of variation in the quantity of urban storm runoff which could result by increasing pervious area, retention and depression storage, and permeability of cover material over a small residential watershed. This objective was to be attained by varying the hydraulic and hydrologic characteristics of the watershed under the same precipitation regimes and comparing the results. Runoff values were determined with the use of the Environmental Protection Agency's (EPA) computer program, "Storm Water Management Model" (6,7,8,9), The study was treated as a simulation model since no previously monitored hydrologic or hydraulic data were available for the study area. The project utilized the hydraulic characteristics of a 154 acre watershed within Farrar Estates, a residential subdivision in southwest Lubbock, Texas. Historical rainfall data were obtained from the U-S, Weather Bureau at the Lubbock Regional Airport and the Texas Agricultural Experimental Station at Lubbock for the period of January 1974 to June 1976.Waller Creek Working Grou

An effect of age on implicit memory that is not due to explicit contamination: implications for single and multiple-systems theories

Recognition memory is typically weaker in healthy older relative to young adults, while performance on implicit tests (e.g., repetition priming) is often comparable between groups. Such observations are commonly taken as evidence for independent explicit and implicit memory systems. On a picture version of the continuous identification with recognition (CID-R) task, we found a reliable age-related reduction in recognition memory, while the age effect on priming did not reach statistical significance (Experiment 1). This pattern was consistent with the predictions of a formal single-system model. Experiment 2 replicated these observations using separate priming (continuous identification; CID) and recognition phases, while a combined data analysis revealed a significant effect of age on priming. In Experiment 3, we provide evidence that priming in this task is unaffected by explicit processing, and we conclude that the age difference in priming is unlikely to have been driven by differences in explicit processing between groups of young and older adults (“explicit contamination”). The results support the view that explicit and implicit expressions of memory are driven by a single underlying memory system